Mechanism of Formononetin in Improving Energy Metabolism and Alleviating Neuronal Injury in CIRI Based on Nontargeted Metabolomics Research.

ABSTRACT: Cerebral ischaemia-reperfusion injury (CIRI), resulting from thrombolytic therapy for ischaemic stroke, presents a considerable challenge during postoperative recovery. Formononetin (FMN) has shown promise in the prevention and treatment of neurological diseases. However, its specific mechanism in ameliorating CIRI remains uncertain. Initially, we established a CIRI rat model to evaluate FMN's therapeutic potential by assessing neurological function, infarct area and pathological changes. Subsequently, we employed metabolomics technology to investigate FMN's impact on metabolite levels in the ischaemic brain tissue of CIRI rats. Based on the metabolomics findings, we validated FMN's effects on nicotinate and nicotinamide metabolism, as well as alanine, aspartate and glutamate metabolism, a

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11850093 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature