ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt/β-Catenin Pathway.

ABSTRACT: One main cause of persistent back discomfort is intervertebral disc degeneration (IDD), with inflammation and extracellular matrix (ECM) degradation playing critical roles. This study investigates the role of ZIP8, a zinc transporter, in IDD pathogenesis, focusing on its effects on inflammatory responses, ECM degradation and Wnt/β-catenin signalling pathway. ZIP8 was identified as a hub gene from the GSE27494 dataset through bioinformatics analysis. The role of ZIP8 was investigated in nucleus pulposus (NP) cells and RAW 264.7 macrophages. An in vivo IDD rat model was used to assess the consequences of ZIP8 overexpression. The involvement of the Wnt/β-catenin pathway was examined, and the effect on macrophage polarisation was analysed. ZIP8 overexpression in NP cells led to increased infla

SUBMITTER: Xu J 

PROVIDER: S-EPMC11850097 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature