Neurocognitive Impairment Among Cryptococcal Meningitis Survivors in Uganda, a Prospective Cohort Study.

ABSTRACT:

Background

Neurocognitive impairment in HIV-associated cryptococcal meningitis survivors remains poorly characterized. We sought to identify risk factors associated with sustained neurocognitive impairment.

Methods

Cryptococcal meningitis survivors from the ASTRO-CM trial underwent neurocognitive assessment at 12 weeks. A composite quantitative neurocognitive performance score (QNPZ-8) was calculated as a mean of 8 independent z-scores. Participants were classified by QNPZ-8 score as having mild (QNPZ-8 ≥-1), moderate (-2 < QNPZ-8 < -1), or severe (QNPZ-8 ≤-2) impairment compared with the reference cohort of HIV-negative Ugandan adults. We compared differences in baseline demographics and clinical and laboratory variables by impairment categories.

Results

One hundred

SUBMITTER: Nsangi L 

PROVIDER: S-EPMC11850114 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature