Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis.

ABSTRACT:

Background

Eosinophilic chronic rhinosinusitis (ECRS) is a subgroup of chronic rhinosinusitis with nasal polyps (CRSwNP), which is a disease characterized by eosinophilic infiltration of the sinonasal mucosa. Few studies that reported the effect of dupilumab on CRSwNP focused on a single phenotype of CRSwNP, such as ECRS.

Objectives

This study aimed to determine the effectiveness of dupilumab in ECRS with postoperative recurrence.

Methods

We retrospectively enrolled 107 patients and assessed the effectiveness of dupilumab by various clinical outcomes. We performed multivariable analysis on nasal polyp score (NPS) and computed tomography score and a meta-analysis of the effect of dupilumab on chronic rhinosinusitis regarding improvement in the NPS.

Results

At 12

SUBMITTER: Nakashima D 

PROVIDER: S-EPMC11850117 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature