Individual variability in cortical representations of tonic pain.

ABSTRACT: When people experience pain in everyday situations, the experience is often long-lasting and fluctuating. However, pain research predominantly focuses on artificial brief and repeated singular painful events. Here, we aimed to approximate clinically relevant pain in 152 sessions from 38 participants who underwent four sessions each. We applied variable levels of contact heat pain to the forearm using a thermode. Participants were asked to continuously rate their pain experience through a potentiometer device. In a whole-brain approach, we related the dynamic fluctuations of cortical activity and connectivity to the time courses of pain. We also explored the variability of cortical processing across participants. In an individual approach, we compared the cortical processing pattern of each

SUBMITTER: Deak B 

PROVIDER: S-EPMC11850121 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature