Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness.

ABSTRACT:

Introduction

The application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs, but often result in aggregation-caused quenching (ACQ) effects, preventing site-specific activation.

Methods

We exploited manganese (Mn²⁺)-pyrochloric acid (PPa) nanocomplexes coordinated using the photosensitizer PPa and metal Mn ion for the treatment of osteosarcoma. The nanocomplexes were precisely co-assembled in water to stably co-deliver Mn²⁺ and PPa, enabling tumor-specific release and fluorescence recovery.

Results

Following laser irradiation, the activated

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11850124 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature