HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis.

ABSTRACT:

Objective

Cardiac function declines with age, impairing exercise tolerance and negatively impacting healthy aging. However, mechanisms driving age-related declines in cardiac function are not fully understood.

Methods

We examined mechanisms underlying age-related cardiac dysfunction using 3- and 24-month-old wild-type mice fed ad libitum or 24-month-old wild-type mice subjected to 70% calorie restriction (CR) starting at 2-month-old. In addition, cardiac aging phenotypes and mitochondrial biogenesis were also analyzed in 25-month-old cardiac-specific Hint1 knockout mice, 24-month-old CAG-Caren Tg mice, and 24-month-old wild-type mice injected with AAV6-Caren.

Results

We observed inactivation of mitochondrial biogenesis in hearts of aged mice. We also showed that activ

SUBMITTER: Sato M 

PROVIDER: S-EPMC11850129 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature