Metabolic dysfunction in mice with adipocyte-specific ablation of the adenosine A2A receptor.

ABSTRACT: It has been well established that adenosine plays a key role in the control of inflammation through G protein coupled receptors and recently shown that it can regulate thermogenesis. Here we investigated the specific requirements of the adenosine A2A receptor (A2AR) in mature adipocytes for thermogenic functionality and metabolic homeostasis. We generated fat tissue-specific adenosine A2AR KO mice to assess the influence of signaling through this receptor on brown and beige fat functionality, obesity, insulin sensitivity, inflammation, and liver function. Fat-specific A2AR KO and WT littermate mice were compared for potential differences in cold tolerance and energy metabolism. In addition, we measured glucose metabolism, AT inflammation, and liver phenotypes in mice of the two genotypes a

SUBMITTER: Verma N 

PROVIDER: S-EPMC11850162 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature