IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury.

ABSTRACT:

Purpose

Acute kidney injury (AKI) secondary to Rhabdomyolysis syndrome represents a life-threatening complication, characterized by notably high incidence and mortality rates. The role of cellular senescence in the progression of AKI has increasingly garnered attention in recent years. Our previous research has demonstrated that remote ischemic postconditioning (RIPC) can attenuate renal cellular senescence and elevation of serum level of interleukin-6 (IL-6) induced by ischemia-reperfusion injury following crush injury. The objective of this study is to investigate the specific role of IL-6 in Rhabdomyolysis-induced AKI (RM-AKI).

Methods

We established a mouse model of RM-AKI by intramuscular injection of glycerol and simulated RM-AKI at the cellular level by treating Hk-2

SUBMITTER: Su H 

PROVIDER: S-EPMC11850272 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature