Investigation of the association between circulating inflammatory proteins and encephalitis risk in Europeans by two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Cytokines are powerful immune response factors that operate at inflammation sites and are also found in the blood. Nevertheless, research on encephalitis and these circulating inflammatory proteins is quite limited.

Methods

This study investigated the potential causal effects of 91 circulating inflammatory proteins on three different types of encephalitis using a two-sample Mendelian randomisation analysis. The data source for encephalitis was the latest Finngen_R12 dataset, released in 2024. The study investigated causal effects mainly using Steiger, MR-Egger, weighted median and inverse variance weighting (IVW) methods. In addition, sensitivity analyses were performed, including heterogeneity assessment, horizontal pleiotropy and leave-one-out techniques.

Res

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11850273 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature