Metabolic imaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treatment.

ABSTRACT: High grade serous ovarian cancer displays two metabolic subtypes; a high OXPHOS subtype that shows increased expression of genes encoding electron transport chain components, increased oxygen consumption, and increased chemosensitivity, and a low OXPHOS subtype that exhibits glycolytic metabolism and is more drug resistant. We show here in patient-derived organoids and in the xenografts obtained by their subcutaneous implantation that the low OXPHOS subtype shows higher lactate dehydrogenase activity and monocarboxylate transporter 4 expression than the high OXPHOS subtype and increased lactate labeling in ¹³C magnetic resonance spectroscopy (MRS) measurements of hyperpolarized [1-¹³C]pyruvate metabolism. There was no difference between the subtypes in PET measurement

SUBMITTER: Chia ML 

PROVIDER: S-EPMC11850285 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature