Novel insights into palatal shelf elevation dynamics in normal mouse embryos.

ABSTRACT: Development of the embryonic palate requires that the palatal shelves (PS), which extend from maxillary processes, to grow bilaterally and vertically alongside the tongue. This growth continues until embryonic day (E) 13.5, after which the PS elevate above the tongue and adhere, completing the process by E14.5. Current models indicate that this elevation process involves a complex vertical-to-horizontal PS reorientation. While earlier studies have implied that reorientation occurs rapidly, the precise timing has not been resolved. Time-restricted pregnancies with a 1-h resolution showed that in 97% of C57BL/6J embryos, the PS were unelevated at E14.0. However, 6 h later, at E14.25, the PS had completed elevation in 80% of embryos, indicating that the PS elevate in a rapid and constrained t

SUBMITTER: Goering JP 

PROVIDER: S-EPMC11850390 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature