MUC5B modulation of early oral biofilm glucose metabolism.

ABSTRACT:

Introduction

Salivary mucin MUC5B has been suggested to support eubiosis in early oral biofilms by regulating the attachment of commensals, while downregulating dysbiotic activities related to dental caries development, such as microbial carbohydrate transport and metabolism.

Methods

To investigate how the metabolism of glucose, a potential driver for dental caries, in early mono- and dual-species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates was affected by the presence of the complex salivary mucin MUC5B, this study employed nuclear magnetic resonance (NMR)-based metabolomics with the interpretation of network integration.

Results and discussion

MUC5B reduced early attachment in the presence of glucose compared wi

SUBMITTER: Robertsson C 

PROVIDER: S-EPMC11850524 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature