Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer.

ABSTRACT:

Introduction

Prostate cancer (PC) is a leading cause of cancer-related deaths among men, often progressing to castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). A subset of CRPC evolves into treatment-emergent neuroendocrine prostate cancer (t-NEPC), an aggressive form characterized by poor prognosis. Currently, there is no reliable biomarker for early detection of t-NEPC. Circular RNAs (circRNAs) have emerged as potential biomarkers due to their stability and tissue-specific expression.

Methods

In this study, we investigated the circRNA landscape during neuroendocrine transdifferentiation (NED) of PC cells using the androgen-sensitive LNCaP and androgen-insensitive DU145 cell lines. To achieve that, we applied CirComPara2 pipeline to publi

SUBMITTER: Pecoraro G 

PROVIDER: S-EPMC11850525 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature