Human reference microbiome profiles of different body habitats in healthy individuals.

ABSTRACT:

Introduction

This study aimed to establish the human reference microbiome profiles in blood, saliva, and stool of healthy individuals, serving as reference values to identify microbiome alterations in human disease.

Methods

The study population consisted of a reference group of healthy adults and a second group consisting of adults with periodontal disease (PD). Blood, saliva, and stool samples were subjected to 16S rRNA sequencing. Reference intervals of alpha diversity indices were calculated. To reduce the effects of inherent limitations of microbiome data, the taxonomic profiles of the reference group were estimated as log-scaled fold change (logFC) in the abundance of microorganisms between two habitats within the subjects.

Results

For stool and saliva microbiome

SUBMITTER: Oh S 

PROVIDER: S-EPMC11850547 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature