Association between frailty and adverse outcomes after cardiac resynchronization therapy: a systematic review and meta-analysis.

ABSTRACT:

Aim

To synthesize evidence, using data from published studies, on the association of frailty with the outcomes after cardiac resynchronization therapy (CRT).

Methods

The systematic search of PubMed, Web of Science, Scopus, and Embase databases was done to identify observational studies (cohort/case-control/cross-sectional) that used an objective method for frailty assessment and had presented adjusted effect sizes. STATA version 15.0 was used to conduct analysis, which was based on random effects model.

Results

Fifteen studies were included. Frailty was found to be associated with an increased risk of in-hospital mortality (odds ratio (OR) 6.96, 95% confidence interval (CI) 5.48, 8.85). The effect of frailty on the response to CRT was not statistically significant (OR

SUBMITTER: Li X 

PROVIDER: S-EPMC11850548 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature