A machine learning approach for estimating Eastern Asian origins from massive screening of Y chromosomal short tandem repeats polymorphisms.

ABSTRACT: Inferring the ancestral origin of DNA evidence recovered from crime scenes is crucial in forensic investigations, especially in the absence of a direct suspect match. Ancestry informative markers (AIMs) have been widely researched and commercially developed into panels targeting multiple continental regions. However, existing forensic ancestry inference panels typically group East Asian individuals into a homogenous category without further differentiation. In this study, we screened Y chromosomal short tandem repeat (Y-STR) haplotypes from 10,154 Asian individuals to explore their genetic structure and generate an ancestry inference tool through a machine learning (ML) approach. Our research identified distinct genetic separations between East Asians and their neighboring Southwest Asians

SUBMITTER: You H 

PROVIDER: S-EPMC11850560 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature