An electroencephalography connectome predictive model of craving for methamphetamine.

ABSTRACT:

Background

Methamphetamine use disorder (MUD) is characterized by prominent psychological craving and its relapsing nature. Previous studies have linked trait impulsivity and abstinence duration to drug use, but the neural substrates of drug cue-induced craving and its relationship with these traits remain unclear in MUD.

Methods

We acquired high-density resting-state electroencephalography (EEG) after participants watched a five-minute video demonstrating methamphetamine use. Combining precise source imaging to reconstruct brain activities with connectome predictive modeling (CPM), we built a craving-specific network within beta band activity from two independent MUD cohorts (N=144 for model development and N=47 for validation).

Results

This network reveals a unified

SUBMITTER: Zhang HB 

PROVIDER: S-EPMC11850752 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature