Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis.

ABSTRACT: Psoriasis is an immune-mediated inflammatory skin disease. IL-22, a proinflammatory cytokine, is implicated in psoriasis pathogenesis; however, there is currently no established biological treatment targeting IL-22 or its receptor, IL-22Rα. Alloferon is a short peptide that has an antiinflammatory effect on skin disorders; however, little is known about its anti-inflammatory activity in psoriasis. We investigated the regulatory role of alloferon in the development of psoriasis in an imiquimod (IMQ)-induced psoriasis model through the regulation of IL-22Rα expression. The expression of IL-22Rα was analyzed by immunofluorescence staining in primary human keratinocytes. The effect of alloferon on the development of psoriasis was investigated in IMQ-induced wild-type and IL-22Rα KO mice. We fo

SUBMITTER: Agura T 

PROVIDER: S-EPMC11850768 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature