Pathophysiological link between carotid atherosclerosis and cerebral white matter lesions.

ABSTRACT: Carotid atherosclerosis is associated with white matter hyperintensity (WMH), potentially resulting in cognitive and gait problems. We assessed the relationship between carotid atherosclerosis patterns and regional WMH, offering insights into possible mechanisms. We reviewed 1,058 consecutive healthy individuals in a health check-up program, who chose both optional carotid doppler ultrasonography and brain magnetic resonance imaging. Total, periventricular, and subcortical WMH volumes were measured using automatic segmentation and quantification. Carotid atherosclerosis stages were defined as: normal, no atherosclerosis; plaque without stenosis, atherosclerotic plaque without stenosis; anatomic stenosis, angiographic stenosis without sonographic flow alteration; and hemodynamic stenosis, s

SUBMITTER: Yang W 

PROVIDER: S-EPMC11850769 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature