Neural mechanisms underlying strain preference behaviour and plasticity in mice.

ABSTRACT: All social animals, including humans, have different social identities that generate unique social interactions. Social preference behaviours, including social integration, prosocial behaviour, and cooperation, have a wide impact on an individual's social life. However, the neural mechanisms underlying social preferences are not yet clear. In this study, using mice as model animals, we investigated strain preference, which is a social preference based on social identification. We revealed, for the first time, that the social behaviour strain preference of mice is heterogeneous; that is, C57 mice prefer to interact with mice of the same strain, whereas KM mice prefer to interact with mice of a different strain. We further confirmed that strain preference in mice can be plastically altered b

SUBMITTER: Peng KZ 

PROVIDER: S-EPMC11850833 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature