Comparative metabolomic analysis reveals shared and unique features of COVID-19 cytokine storm and surgical sepsis.

ABSTRACT: The clinical manifestations of the cytokine storm (CS) associated with COVID-19 resemble the acute phase of sepsis. Metabolomics may contribute to understanding the specific pathobiology of these two syndromes. The aim of this study was to compare serum metabolomic profiles in CS associated with COVID-19 vs. septic surgery patients. In a retrospective cross-sectional study, serum samples from patients with CS associated with COVID-19, with and without comorbidity, as well as serum samples from patients with surgical sepsis were investigated. Targeted metabolomic analysis was performed on all samples using LC-MS/MS. Analysis revealed that similar alterations in the serum metabolome of patients with COVID-19 and surgical septic patients were associated with amino acid metabolism, nitrogen me

SUBMITTER: Russkikh IV 

PROVIDER: S-EPMC11850835 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature