Exploring thymic stromal lymphopoietin in the breast cancer microenvironment: A preliminary study.

ABSTRACT: Cancer participates in the immune response by releasing several factors, such as cytokines and chemokines, which can alter the ability of the immune system to identify and eradicate cancer. Notably, the role of thymic stromal lymphopoietin (TSLP) in breast cancer (BC) is currently controversial and unclear. The present study characterized the role of TSLP in BC and its interaction with peripheral blood mononuclear cells, focusing on the CD14⁺CD16⁺ monocyte population via the secretome released by BC cells. The UALCAN and Gene Expression Profiling Interactive Analysis tools were employed to define TSLP expression in BC, and its levels in different BC subtype cell lines were validated using reverse transcription-quantitative PCR and ELISA. In addition, TIMER 2.0 was use

SUBMITTER: Marcella S 

PROVIDER: S-EPMC11851057 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature