Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review.

ABSTRACT:

Introduction

Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics-driven research has revealed associations between vascular abnormalities and transcriptomic alterations in brain vascular cells, particularly endothelial cells (ECs) and pericytes (PCs). However, the impact of these molecular changes on dementia remains unclear.

Methods

We conducted a comparative analysis of gene expression in ECs and PCs across neurodegenerative conditions, including Alzheimer's disease (AD), Huntington's disease, and arteriovenous malformation, utilizing transcriptomic data from published postmortem human tissue studies.

Results

We identified differentially expressed genes (DEGs) consistently dysregulat

SUBMITTER: Sewell M 

PROVIDER: S-EPMC11851133 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature