Long-range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, the mechanisms underlying AD-associated changes in long-range circuits remain poorly understood.

Methods

In this study, we used viral tracing and fluorescence micro-optical sectioning tomography (fMOST) imaging to investigate whole-brain changes in the input circuit of the frontal cortex of 5×FAD mice.

Results

Pathological axonal degeneration was widely observed in upstream regions, including the cortex, hippocampus, and thalamus, across all AD brains examined. The proportion of input neurons projecting to parvalbumin-expressing neurons, compared to those projecting to somatostatin-expressing neurons, decreased in the hippocampus a

SUBMITTER: Ren M 

PROVIDER: S-EPMC11851137 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature