CA3 Pyramidal Neuron Activation Promotes Cognitive Resilience to Inflammation-Induced Cognitive Inflexibility.

ABSTRACT:

Aims

Cognitive dysfunction represents a prominent symptom in numerous prevalent mental illnesses, with systemic inflammation induced by cytokines recognized as a critical factor contributing to cognitive impairments. However, a significant proportion of individuals exposed to systemic inflammation do not develop cognitive dysfunction; instead, they exhibit adaptive responses to this adverse condition. This study aims to investigate the neural activity patterns within the hippocampus and the potential mechanisms that mediate cognitive resilience, particularly in the context of inflammation.

Methods

We investigated the effects of systemic IL-1β (Interleukin-1β) on learning, spatial memory, and cognitive flexibility using the Barnes maze test (BMT). We further analyzed specific

SUBMITTER: Zuo W 

PROVIDER: S-EPMC11851139 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature