Hippocampal neuronal loss and cognitive decline in LATE-NC and ADNC among community-dwelling older persons.

ABSTRACT:

Introduction

This study investigates the inter-related roles of hippocampal neuronal loss (HNL), limbic-predominant age-related TAR-DNA binding protein of 43 kDa (TDP-43) encephalopathy neuropathologic changes (LATE-NC), and Alzheimer's disease neuropathologic changes (ADNC) on cognitive decline.

Methods

Participants underwent annual cognitive testing and autopsy. HNL, ADNC, LATE-NC, and other age-related pathologies were evaluated. Regression and mixed-effects models examined the association of HNL with ADNC and LATE-NC, and separately with cognitive decline. Path analyses examined the extent to which associations of LATE-NC and ADNC with cognitive decline were attributable to HNL.

Results

LATE-NC was associated with more severe HNL, but ADNC was associated only afte

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC11851160 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature