Alzheimer's disease patients have smaller venous drainage system compared to cognitively healthy controls.

ABSTRACT:

Introduction

One of the pathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid beta 42 (Aβ42). Decreased venous drainage may enhance Aβ42 accumulation. We aimed to compare venous cross-sectional area (CSA) of AD patients to cognitively healthy controls.

Methods

All patients underwent neurocognitive evaluation and brain magnetic resonance imaging, including time-of-flight sequence. Venous CSA was measured at the jugular foramen level.

Results

Thirty-nine AD/mild cognitive impairment patients and 20 cognitively healthy controls were included. Total venous CSA was smaller in the cognitively impaired group (mean CSA 139.77 mm² [SD: 32.22] vs 166.55 mm² [SD: 33.1], p = 0.004]. When divided, both internal jugular and non-jugu

SUBMITTER: Pardo K 

PROVIDER: S-EPMC11851167 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature