Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin.

ABSTRACT:

Background

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction to medication that presents within 72 hours of exposure with erythematous papules and plaques with overlying pustules. The immunopathogenesis and predisposing factors of AGEP are not well characterized.

Objective

To better understand the genetic risk factors and single-cell immunopathogenesis of AGEP, we longitudinally characterized a patient with recurrent AGEP after an initial episode triggered by vancomycin.

Methods

A clinical timeline over an 8-year period was paired with skin testing, histopathology, and immunogenetic and other testing at 3 time points. Skin biopsies performed on affected skin (positive vancomycin-delayed intradermal testing [IDT]) and unaffected c

SUBMITTER: Mukherjee EM 

PROVIDER: S-EPMC11851205 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature