Non-Targeted Analysis of Environmental Contaminants and Their Associations with Semen Health Factors in Men from New York City.

ABSTRACT: Characterizing the chemical composition of semen can provide valuable insights into the exposome and environmental factors that directly affect seminal and overall health. In this study, we compared molecular profiles of 45 donated semen samples from general population New York City participants and examined the correlation between the chemical profiles in semen and fertility parameters, i.e., sperm concentration, sperm motility, sperm morphology, and semen volume. Samples were prepared using a protein precipitation procedure and analyzed using liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). Non-targeted analysis (NTA) revealed 18 chemicals not previously reported in human exposome studies, with 3-hydroxyoctanedioic acid, a cosmetic additive, emerging as a p

SUBMITTER: Johnson TA 

PROVIDER: S-EPMC11851215 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature