Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast.

ABSTRACT:

Importance

Inflammation impacts cancer risk and tumor biological processes, yet studies linking it to social and environmental risk factors are lacking.

Objective

To investigate the association of neighborhood deprivation and air pollution with breast adipose inflammation as well as the association between crown-like structures of the breast (CLS-B) and DNA methylation in Black and White women.

Design, setting, and participants

This cross-sectional study analyzed women with and without breast cancer participating in the National Cancer Institute-Maryland Breast Cancer Study, most of whom were recruited between January 1, 1993, and December 1, 2003, from the University of Maryland Medical Center and surrounding hospitals in the Baltimore, Maryland, area. A small subset

SUBMITTER: Harris AR 

PROVIDER: S-EPMC11851241 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature