Comparison of Two Interferon-Gamma Release Assays for Pediatric Tuberculosis Infection.

ABSTRACT:

Introduction

Identifying tuberculosis infection (TBI) using interferon-gamma release assays (IGRAs) is a primary component of clinical and public health efforts to prevent pediatric tuberculosis (TB). Pediatric data comparing the 2 IGRAs in the United States are very limited. We compared the performance of the 2 IGRAs among a large pediatric cohort tested for TBI and assessed whether discordance might be due to quantitative results close to test cutoff values.

Methods

Children aged 0-15 years with both T-SPOT.TB (T-SPOT) and QuantiFERON-TB Gold In-Tube (QFT-GIT) tests were identified from a US multicenter study enrolling people at elevated risk of TBI or progression to TB disease. Results were compared using McNemar's Chi-square tests with stratification by age category and

SUBMITTER: Gaensbauer JT 

PROVIDER: S-EPMC11851244 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature