Metabolic connectivity has greater predictive utility for age and cognition than functional connectivity.

ABSTRACT: Recently developed high temporal resolution functional (18F)-fluorodeoxyglucose positron emission tomography (fPET) offers promise as a method for indexing the dynamic metabolic state of the brain in vivo by directly measuring a time series of metabolism at the post-synaptic neuron. This is distinct from functional magnetic resonance imaging (fMRI) that reflects a combination of metabolic, haemodynamic and vascular components of neuronal activity. The value of using fPET to understand healthy brain ageing and cognition over fMRI is currently unclear. Here, we use simultaneous fPET/fMRI to compare metabolic and functional connectivity and test their predictive ability for ageing and cognition. Whole-brain fPET connectomes showed moderate topological similarities to fMRI connectomes i

SUBMITTER: Deery HA 

PROVIDER: S-EPMC11851278 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature