Accelerometer-measured physical activity timing with incident dementia.

ABSTRACT:

Introduction

Moderate to vigorous physical activity (MVPA) is linked to lower dementia risk, though the optimal timing remains unclear.

Methods

Using accelerometer-measured MVPA data from 90,329 dementia-free UK Biobank participants with at least 2 years of follow-up, we assessed associations between MVPA patterns (morning, afternoon, evening, mixed, inactive) and dementia risk via multivariable-adjusted Cox proportional hazards models.

Results

Compared to the inactive group, participants with a tendency of morning MVPA had a lower risk of all-cause dementia (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.40-0.90) and Alzheimer's disease (AD) risk (HR: 0.44, 95% CI: 0.22-0.86). No association of the other time point with all-cause dementia was observed. Addi

SUBMITTER: Ning Y 

PROVIDER: S-EPMC11851314 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature