Early midlife ovarian removal is associated with lower posterior hippocampal function.

ABSTRACT:

Introduction

Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.

Methods

Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging. Hippocampal activity along the anteroposterior axis during associative encoding and retrieval was compared among three groups (BSO [n = 28], BSO+ET [n = 35], AMCs [n = 40]).

Results

Both BSO groups (wi

SUBMITTER: Brown A 

PROVIDER: S-EPMC11851323 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature