Characterization of Klebsiella pneumoniae Isolates Resistant to Cefiderocol from Hospitals and Outpatient Settings in Croatia.

ABSTRACT:

Background/objectives

We conducted this study to evaluate the genotypic and phenotypic profiles of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates, exhibiting resistance to cefiderocol (FDC), focusing on antibiotic susceptibility, β-lactamase production, the genetic environment of bla_CARB and bla_ESBL genes and molecular epidemiology. FDC is now a last-line antibiotic for severe infections due to CRKP.

Methods

Susceptibility to a wide range of antibiotics was determined by the disk diffusion and broth microdilution method. Carbapenemases were screened by a modified Hodge test while carbapenem hydrolysis was investigated using mCIM and eCIM tests. The screening for β-lactamase and fluoroquinolone cluster resistance genes wa

SUBMITTER: Bedenic B 

PROVIDER: S-EPMC11851357 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature