Antimicrobial Susceptibility of Toxin-Producing Corynebacterium diphtheriae and C. ulcerans in Belgium.

ABSTRACT: Background/Objectives: Despite a significant reduction in diphtheria incidence and mortality due to vaccination, antitoxin therapy and antibiotic treatments, a concerning resurgence is occurring in Europe. Resistance to penicillins and macrolides is emerging, resulting in a growing challenge for diphtheria management. This retrospective study aims to evaluate and compare antibiotic susceptibilities of both toxigenic Corynebacterium diphtheriae and C. ulcerans. Methods: Susceptibilities were assessed using broth microdilution-the gold standard-disk diffusion and the gradient method, and analyzed on the basis of the EUCAST breakpoint tables for the interpretation of MICs and zone diameters. Antimicrobial resistance genes and mutations were detected by analyzing wh

SUBMITTER: Janssen Z 

PROVIDER: S-EPMC11851535 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature