Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study.

ABSTRACT: Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four AAA patients with ILT were enrolled. Patient-specific models of the aorta and branch arteries were constructed followed by CFD simulations. NO concentration was modeled based on endothelial shear stress response and its transport within the arterial lumen and wall. Hemodynamic parameters, including wall shear stress (WSS) and its derivatives, were analyzed alongside NO distribution. ILT accumulation was primarily located in the infrarenal abdominal aorta. Regions of decreased NO concentration c

SUBMITTER: Li S 

PROVIDER: S-EPMC11851545 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature