Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant Pseudomonas aeruginosa.

ABSTRACT: Background/Objectives: Antibiotic resistance in pathogenic bacteria poses a critical global health threat, with multidrug-resistant (MDR) strains increasingly undermining conventional treatments. Among these, Pseudomonas aeruginosa is a high-priority pathogen due to its resistance to carbapenems and frequent presence in hospital settings, contributing to severe healthcare-associated infections. This study aimed to isolate and characterize novel bacteriophages from environmental wastewater samples that could specifically target MDR P. aeruginosa. Methods: Two bacteriophages, M8-2 and M8-3, were isolated from wastewater in Monterrey, Mexico. A genomic analysis classified M8-2 and M8-3 within the Caudoviridae family, and next-generation sequencing (NGS) was

SUBMITTER: Rodriguez-Recio FR 

PROVIDER: S-EPMC11851605 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature