Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase.

ABSTRACT: Copper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of copper have been found in the blood or tumors of patients with various forms of cancer and may affect cancer severity and response to treatment. Copper is required for the activation of cytochrome c oxidase (CcO), the mitochondrial complex that facilitates oxidative phosphorylation (OXPHOS)-mediated ATP production. We recently reported that the increased activation of CcO underlies the acquisition of treatment resistance in glioblastoma (GBM) cells. However, the potential role of copper in GBM progression or treatment resistance has not been investigated. Here, we present evidence that exposure to 20 µM copper, the maximum allowable limit for public water supplies set by the

SUBMITTER: Oliva CR 

PROVIDER: S-EPMC11851629 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature