Bactericidal Effect of a Novel Phage Endolysin Targeting Multi-Drug-Resistant Acinetobacter baumannii.

ABSTRACT:

Background/objectives

Infections with antibiotic-resistant Gram-negative pathogens represent a major global threat to public health. Acinetobacter baumannii is a highly important nosocomial pathogen causing severe and life-threatening infections, like pneumonia, wound infections, or sepsis. It is often resistant even against last-resort antibiotics, such as carbapenems, and can persist in healthcare settings. Artilysin^®s are a novel class of endolysins targeted against multidrug-resistant bacteria.

Methods

Antibacterial activity of Art-Top3 was determined by broth microdilution, in vitro assays and in the Galleria mellonella infection model. The toxicity of Art-Top3 on red blood cells, endothelial and epithelial cells was analyzed using the MTT assay

SUBMITTER: Garcia Torres S 

PROVIDER: S-EPMC11851708 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature