Downregulation of DNAJC12 Expression Predicts Worse Survival for ER-Positive Breast Cancer Patients.

ABSTRACT:

Background

DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12) encodes a member of the molecular chaperone Hsp40/DnaJ family, which are important protein folding and proteostasis regulators. Its role as a biomarker has been studied for a limited number of cancer types. Objectives: Here, we sought to investigate the potential of DNAJC12 mRNA and protein expression as a prognostic and predictive biomarker for breast cancer (BC).

Methods

Using in silico analysis and data from immunohistochemistry analysis (IHC) of 292 samples from patients with primary BC, we determined the expression pattern and prognostic value of DNAJC12 mRNA and protein expression.

Results

From online publicly available data, we were able to identify the transcripts of DNAJC12 as differential

SUBMITTER: Gatti PHF 

PROVIDER: S-EPMC11851741 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature