Androgen Receptor Expression Governs the Seasonal Inhibition of Testicular Development and Subsequent Recovery in Rattus norvegicus caraco.

ABSTRACT: Commonly in seasonal breeding animals, testicular development is inhibited prior to Sertoli cell maturation when environmental conditions become unfavorable, with recovery occurring once conditions improve. However, the precise molecular mechanisms governing this process remain unclear. We investigated the role of androgen receptor (AR) in the seasonal regulation of testicular development in a wild population of Rattus norvegicus caraco, a subspecies of brown rats in Northeast China residing in high-latitude regions, known for its seasonal reproductive patterns. Our results revealed a significant increase in Ar mRNA expression in wild rats with small testes less than 0.2 g and body weights ranging between 80 and 100 g during the nonbreeding season. Further examinations of

SUBMITTER: Ying Y 

PROVIDER: S-EPMC11851772 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature