The Secretome of the Inductive Tooth Germ Exhibits Signals Required for Tooth Development.

ABSTRACT: Teeth develop from reciprocal signaling between inductive and receptive cells. The inductive signals for tooth development are initially in the epithelium of the developing branchial arch, but later shift to the underlying mesenchyme of a developing tooth germ. The inductive signals that are needed for tooth development have not yet been fully identified. Our lab previously provided a basis for bioengineering new teeth by separating the tooth germ's epithelial and mesenchyme cells into a single cell population and recombing them. This approach, however, is not clinically applicable as the cells lose their inductive ability when expanded in vitro. In this study, we investigate whether the secretome and small extracellular vehicles (sEV) derived from inductive tooth germ mesenchyme can contr

SUBMITTER: Birjandi AA 

PROVIDER: S-EPMC11851894 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature