Characterization of Exosome-like Nanoparticles from Saffron Tepals and Their Immunostimulatory Activity.

ABSTRACT: Plant exosomes exhibit high stability and easy absorption, and have emerged as promising bioactive tools due to their potential health benefits and biomedical applications. Saffron tepals contain abundant metabolites with potential therapeutic properties and were used for exosome extraction by ultracentrifugation and gradient purification. The exosomes showed an average particle size of 151.5 ± 79.6 nm and exhibited a spherical morphology. Five well-conserved miRNAs-miR157, miR166, miR168, miR396, and miR398-were identified in the exosomes, which are involved in the coordination of growth and physiological plant responses with endogenous and environmental abiotic and biotic signals, and their potential targets in mammals are upregulated in specific cancer types and associated with inflamma

SUBMITTER: Martinez Fajardo C 

PROVIDER: S-EPMC11851917 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature