Analysis and Visualization of Confounders and Treatment Pathways Leading to Amputation and Non-Amputation in Peripheral Artery Disease Patients Using Sankey Diagrams: Enhancing Explainability.

ABSTRACT: Background/Objectives: This study uses Sankey diagrams to analyze treatment pathways in patients with peripheral artery disease (PAD), which is a vascular condition characterized by atherosclerotic occlusion of the arteries, particularly in the lower limbs, affecting up to 14% of the general population. This study focuses on the treatment pathways that lead to amputation versus those that do not, utilizing the STARR dataset and the All of Us dataset. Methods: The study utilized Sankey diagrams to visualize treatment pathways, highlighting the progression from initial treatments to outcomes. Odds ratio analysis was performed to quantify the association between treatment pathways and outcomes. Recognizing potential confounders, analyses were conducted by filtering patien

SUBMITTER: Korutla R 

PROVIDER: S-EPMC11851926 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature