The case for development of a core outcome set (COS) and supplemental reporting guidelines for influenza vaccine challenge trial research in swine.

ABSTRACT: Previously, we systematically reviewed more than 20 years of influenza vaccine challenge trial research in pigs to answer the question, "does vaccinating sows protect offspring?" Overall, most studies were well designed but clinical heterogeneity made between-study comparisons challenging. Studies varied by samples, outcomes, and assays selected for measurement. Additionally, data essential for inclusion of findings in meta-analyses were often insufficiently reported and as a result, summary effect measures were either not derived or were not meaningful. Clinical heterogeneity and reporting issues complicate and limit what can be learned cumulatively from research and both represent two types of avoidable research waste. Here, we illustrate each concern using data collected tangentially du

SUBMITTER: Keay S 

PROVIDER: S-EPMC11851948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature