Periplaneta americana Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting N-Methyl-D-Aspartate Receptor Activation.

ABSTRACT: Neurocytotoxicity elicited by N-methyl-D-aspartate receptors (NMDAR) is a substantial contributor to neurodegenerative diseases. Our current study expands on the previous findings in which Periplaneta americana (L.) extract (PAS840) was shown to protect PC12 cells from hydrogen peroxide-induced injury. In this investigation, we performed LC-MS/MS and peptidomics analyses on the constituents of PAS840. Considering Alzheimer's disease (AD) as the primary focus, we utilized network pharmacology and molecular-docking techniques to predict PAS840's influence on AD targets. We established a glutamate (Glu)-induced PC12 cell injury model to conduct a comprehensive examination of PAS840's effects on pivotal cellular parameters, including intracellular Ca²⁺ levels, superoxi

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11851986 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature