Butyrate Prevents Obesity Accompanied by HDAC9-Mediated Browning of White Adipose Tissue.

ABSTRACT:

Background/objectives

Mounting evidence indicates that the short-chain fatty acid butyrate protects against obesity and associated comorbidities, partially through the induction of adipose tissue thermogenesis. However, the effects of butyrate on white adipose tissue (WAT) browning and its molecular mechanism are still elusive. The objective of this study was to investigate butyrate-induced thermogenesis in white adipose tissue and its underlying mechanism.

Methods

We studied the effects of butyrate on diet-induced obesity in the humanized APOE*3-Leiden.CETP transgenic mouse model and explored factors related to white adipose browning. Specifically, mice were challenged with a high-fat diet supplemented with butyrate. Adiposity was measured to assess obesity development. Ene

SUBMITTER: Yang J 

PROVIDER: S-EPMC11852213 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature