Liver manifestations in autosomal dominant polycystic kidney disease (ADPKD) and their impact on quality of life.

ABSTRACT:

Background

ADPKD is the most prevalent monogenic kidney disease with an estimated incidence of 1:1000. The condition is characterized by the formation of kidney cysts, which can cause kidney function loss and bear a significant risk of advancing to kidney failure. This study examined the prevalence of hepatic cysts in individuals with ADPKD, and the possible influence of these cysts on liver function and quality of life. Furthermore, the relationship between hepatic cysts and genotype was analysed.

Methods

Clinical data from 880 patients with ADPKD were analysed, including longitudinal patient data, genetic information, and laboratory parameters.

Results

The prevalence of hepatic cysts in adult ADPKD patients was 81.71%, consistent with previous studies. Prevalence in

SUBMITTER: Arjune S 

PROVIDER: S-EPMC11852259 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature